Estudo sugere que ftalatos, componente químico de plásticos, ‘afemina’ meninos

Os ftalatos influenciariam o comportamento dos meninos. Foto BBC.

Uma pesquisa feita nos Estados Unidos indica que a exposição de gestantes a certas substâncias presentes na composição de plásticos pode mudar o comportamento de seus filhos do sexo masculino, fazendo com que eles fiquem “mais femininos”.

De acordo com o estudo, de pesquisadores da University of Rochester, alguns tipos de compostos químicos conhecidos como ftalatos interferem no desenvolvimento do cérebro, bloqueando a ação do hormônio masculino testosterona nos bebês.

Os ftalatos são encontrados em embalagens para alimentos, certos tipos de pisos e cortinas plásticas, colas, corantes e artigos têxteis, entre outros itens. Há vários tipos dessa substância, e alguns simulam o efeito do hormônio feminino estrogênio.

A equipe de pesquisadores, liderada por Shanna Swan, testou amostras de urina de gestantes a partir da metade da gravidez procurando por traços de ftalatos.

As mulheres deram à luz 74 meninos e 71 meninas. Quando os meninos tinham entre quatro e sete anos, os pesquisadores perguntaram às mães sobre seus brinquedos e brincadeiras preferidos.

Eles verificaram que a presença de dois tipos de ftalatos, o DEHP e o DBP, tinha relação com a forma de brincar das crianças.

Os meninos expostos a altas doses desses compostos apresentaram menor tendência a brincar com carros, trens ou armas de brinquedo e a participar de brincadeiras mais agressivas, como lutas.

Banidos na UE

Já se sabia que as substâncias interferem na ação de hormônios no organismo e, por isso, elas foram banidas de brinquedos na União Europeia há alguns anos.

A equipe responsável pelo novo estudo também já havia provado a associação entre a substância e meninos nascidos com anomalias nos genitais.

“Nossos resultados precisam ser confirmados, mas são intrigantes em muitos aspectos”, disse Swan.

“Não apenas são consistentes com descobertas anteriores, associando os ftalatos a alterações no desenvolvimento dos genitais, mas também são compatíveis com conhecimentos atuais sobre como os hormônios moldam as diferenças sexuais no cérebro e, portanto, o comportamento.”

A pesquisa foi divulgada na publicação científica International Journal of Andrology.

Release da University of Rochester: Pilot Study Relates Phthalate Exposure to Less-Masculine Play by Boys

A study of 145 preschool children reports, for the first time, that when the concentrations of two common phthalates in mothers’ prenatal urine are elevated their sons are less likely to play with male-typical toys and games, such as trucks and play fighting.

The University of Rochester Medical Center-led study is published in the International Journal of Andrology.

Because testosterone produces the masculine brain, researchers are concerned that fetal exposure to anti-androgens such as phthalates – which are pervasive in the environment – has the potential to alter masculine brain development, said lead author Shanna H. Swan, Ph.D., professor of Obstetrics and Gynecology, director of the URMC Center for Reproductive Epidemiology, and an expert in phthalates.

“Our results need to be confirmed, but are intriguing on several fronts,” Swan said. “Not only are they consistent with our prior findings that link phthalates to altered male genital development, but they also are compatible with current knowledge about how hormones mold sex differences in the brain, and thus behavior. We have more work to do, but the implications are potentially profound.”

Phthalates are chemicals used to soften plastics. Recent studies have shown that the major source of human exposure to the two phthalates of most concern (DEHP and DBP) is through food. These phthalates are used primarily in polyvinyl chloride (PVC), so any steps in the processing, packaging, storage, or heating of food that use PVC-containing products can introduce them into the food chain.

Phthalates are also found in vinyl and plastic tubing, household products, and many personal care products such as soaps and lotions. Phthalates are becoming more controversial as scientific research increasingly associates them with genital defects, metabolic abnormalities, and reduced testosterone in babies and adults. A federal law passed in 2008 banned six phthalates from use in toys such as teethers, play bath items, soft books, dolls and plastic figures.

In Swan’s study, higher concentrations of metabolites of two phthalates, di(2-ethylhexyl) phthalate (DEHP), and dibutyl phthalate (DBP), were associated with less male-typical behavior in boys on a standard play questionnaire. No other phthalate metabolites measured in-utero was linked to the less-masculine behavior. Girls’ play behavior was not associated with phthalate levels in their mothers, the study concluded.

Swan’s interest in phthalates stems from an investigation into the environmental causes of reproductive health problems. Since 1998 she has led the federally funded, multi-center Study for Future Families (SFF), which established a large database from which to explore various scientific questions about toxins.

The current study focused on a small sample of SFF mothers who delivered children between 2000 and 2003. The mothers provided urine samples around the 28^th week of pregnancy. The urine was analyzed for phthalate metabolites by the Centers for Disease Control and Prevention (CDC).

Swan hypothesized that phthalates may lower fetal testosterone production during a critical window of development – somewhere within eight to 24 weeks gestation, when the testes begin to function – thereby altering brain sexual differentiation.

To explore the question, researchers reconnected with mothers from the SFF sample and asked them to complete a standard research questionnaire, called the Preschool Activities Inventory (PSAI), for their children ages 3 1/2 to 6 1/2 years.

The PSAI is designed to discriminate play behavior within and between the sexes, and in the past has been shown to reflect the endocrine-disrupting properties of other toxins, such as PCBs and dioxins. The PSAI addressed three aspects of play: types of toys children choose (trucks versus dolls), activities (rough-and-tumble play, for example), and child characteristics.

However, researchers were concerned about how the choice of toys available in any given household might skew results, so in addition they asked about parental views toward atypical play. For example, the survey asked, “What would you do if you had a boy who preferred toys that girls usually play with?” The possible answers included “strongly encourage” (him to play this way) to “strongly discourage.”

The final survey scores are designed to reflect sex-typical play. Higher scores meant more male-typical play and lower scores meant more female-typical play.

Researchers then examined boys play-behavior scores in relation to the concentration of phthalate metabolites in their mothers’ prenatal urine samples, finding that higher concentrations of DEHP and DBP metabolites were associated with less masculine play behavior scores.

Earlier studies by Swan and others have shown that phthalate exposure during pregnancy might affect the development of genitals of both male rodents and baby boys. Scientists refer to this cluster of genital alterations as the “phthalate syndrome,” and research suggests that in rodent pups, the syndrome can have adverse consequences for later sexual development.

If endocrine disrupters such as phthalates can impair genital development and hormone levels in the body, the play-behavior study noted, then a deeper examination of how these chemicals impact the brain is warranted.

The U.S. Environmental Protection Agency, the National Institutes of Health and the state of Iowa provided funding for the study. Co-authors from URMC include Bernard Weiss, Ph.D., professor, Department of Environmental Medicine, and Fan Liu, M.S., database manager for the Center for Reproductive Epidemiology. From other institutions: Amy Sparks, Ph.D., of the University of Iowa Hospitals and Clinics; Christina Wang, M.D., UCLA School of Medicine; J. Bruce Redmon, M.D., University of Minnesota School of Medicine; Robin Kruse, Ph.D., University of Missouri School of Medicine; and  Melissa Hines, Ph.D., University of Cambridge, United Kingdom.

Reportagem da BBC Brasil, publicada, com informações complementares, pelo EcoDebate, 17/11/2009

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